Clinical Pharmacology: Current Topics and Case Studies

Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.
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http://hotfile.com/dl/106805844/8da1ffb/Pharmacology.pdf.html

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy

This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system.


Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development.
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http://hotfile.com/dl/96283806/884718a/Principles_of_Pharmacology.chm.html

Katzung & Trevor's Pharmacology Examination and Board Review, Ninth Edition (McGraw-Hill Specialty Board Review) - 2010 Edition

The most trusted and efficient pharmacology review – complete with 1000+ Q&As -- and now in full color


5 STAR DOODY'S REVIEW!

"The authors have designed this book to foster the mastery of pharmacology for students who have to pass course, module, or certification examinations....This is one of the best review books in pharmacology. The latest version is far superior, both in content and presentation, to previous versions. I give it my highest recommendation."--Doody's Review Service

From the authors of Basic and Clinical Pharmacology, the leading pharmacology textbook, here is the newest edition of the best review book available for medical pharmacology course exams and board examinations. This skill-building guide comes with over 1000 review questions and answers –- far more than most other pharmacology reviews –- and a chapter-based approach that facilitates use with course notes or larger texts.

Features:

* A new full-color presentation

* Organized to reflect course syllabi, focusing on the clinical use and pharmacology of drug categories, rather than individual drugs

* Two complete practice exams

* A valuable appendix of test-taking strategies

* Chapters that include valuable learning aids such as:

--Short discussion of the major concepts that underlie basic principles or drug groups

--Explanatory figures and tables

--Review questions followed by answers and explanations

--Drug Trees in drug-oriented chapters that visually organize drug groups

--A list of high-yield terms and definitions you need to know

* Skill Keeper questions that prompt you to review previous material to understand links between related topics

* A checklist of tasks you should be able to do, once you have finished the chapter

* Summary Tables that list the important drugs and include key information about their mechanisms of action, effects, clinical uses, pharmacokinetics, drug interactions, and toxicities
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http://hotfile.com/dl/91813892/7e54a71/KATZUNG.CHM.html

Drugs and Pregnancy: A Handbook

This practical handbook will assist the physician and nurse prescriber in understanding the effects of drug exposure during pregnancy. Numerous tables and boxes provide information on drug classifications and regimens, as well as highlighting adverse effects and TERIS and FDA risk ratings. Sources of further information are provided where appropriate, and full references are available on the book's website www.drugs-and-pregnancy.com. The book provides detailed guidelines on prescribing drugs in all classes, and for a wide variety of diseases and disorders, during pregnancy. Opening with a helpful analysis of potential risks and benefits of prescribing in pregnancy, the book moves on to consider the implications of both medications for pre-existing conditions and those that develop during pregnancy, including antimicrobials, drugs for cardiovascular disease, asthma and endocrine disorders, antineoplastic agents, skin preparations, epilepsy treatments and psychiatric drugs. Invaluable guidance on anesthetic administration and the use of pain relieving medication during pregnancy and labor, and helpful advice on the possible side-effects associated with over-the-counter preparations such as cold and 'flu remedies, antihistamines and nutritional supplements is also provided.
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Statins: Indications and Uses, Safety and Modes of Action

This book focuses on statins which are a relatively new group of drugs used to lower blood cholesterol levels. A high cholesterol level increases a person's risk of having a heart attack or stroke. The long-term use of statins reduces the risk of such an event and can increase the life expectancy of people with a history of heart disease. The statins work by blocking an enzyme in the body that is involved in the production of LDL cholesterol, especially in the liver. This enzyme is known as HMG coenzyme A reductase. The statins are the most effective group of drugs for lowering the levels of LDL cholesterol in the body. Potential side-effects include muscle cramps and gastrointestinal upsets. These are usually resolved on temporarily lowering the dose. Liver enzyme derangements may occur, which generally return to normal after briefly discontinuing the drug. Some report headaches. Other side-effects occur rarely.
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http://www.filesonic.com/file/36409735

Handbook of Drugs in Intensive Care: An A - Z Guide - 2010 Edition

The fourth edition of this compact, practical pocketbook provides easy access for the reader with an A-Z listing of every drug and accompanying advice on its correct administration and potential adverse effects. It is an invaluable resource for all healthcare professionals working in the intensive care setting.


Numerous treatment options are available to intensive care staff; this requires detailed knowledge of routes of administration and contra-indications to use in certain clinical conditions. Now in its fourth edition, this concise, practical handbook to drugs and prescribing for intensive care gives up-to-date advice on established drugs as well as providing advice on those recently approved. The book is divided into two sections: an A-Z guide to many of the drugs available, with concise information on each drug, including uses, limitations, administration directions and adverse effects. The second section contains topics relevant to the critically ill patients, including factors that may affect drug prescribing and management of medical emergencies. There is also a key data section showing weight conversions, BMI and corresponding dosage calculations, and an invaluable chart indicating drug compatibility for IV administration. This is an invaluable resource for doctors, nurses, and pharmacists caring for critically ill patients.
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http://www.filesonic.com/file/34708467/drugs.pdf

Usmle Step1 Webprep From Kaplan - Pharmacology

Pharmacology portion of Kaplan USMLE Step 1.


WebPrep is the perfect fit for students interested in reinforcing their knowledge of Step 1 topics and concepts. You'll benefit from prepping with the highest-yield USMLE Step 1 content available. Realistic practice questions will reinforce your understanding of key concepts.

Real Media audio format and notes in microsoft word format.

Topics and Runtime in minutes
 
General Principles



Signalling Mechanisms    --- 24:43


Autonomics


Anatomy of ANS    --- 16:24


Blood Pressure Control Mechanisms    --- 08:46


Cholinergic Receptors    --- 13:09


M&N cholinoceptor locations & results of mechanisms    --- 14:07


Cholinomimetics    --- 19:05


Cholinergic Receptors Antagonists    --- 24:11


Adrenergic Receptors    --- 16:56


Alpha & Beta Adrenoceptors    --- 43:11


Adrenergic Receptors Antagonists    --- 20:14


Cardiovascular & Renal


Antiarrhymic Drugs    --- 40:40


Angiotensin System & Drugs    --- 10:15


Heart Failure    --- 30:19


Angina Drugs    --- 16:17


Diuretics    --- 29:28


Diuretics Pt. II    --- 17:50


Antihyperlidpidemics    --- 12:15


Central Nervous System


CNS Neurotransmitters & Drugs    --- 19:45


Anticonvulsants    --- 22:54


Dopamine, Parkinsonism, Schizophrenia    --- 42:54


Dopamine, Parkinsonism, Schizophrenia (Pt. II)    --- 36:28


Antinflammatory Drugs


NSAIDs & Antiinflammatory Drugs    --- 32:18


NSAIDs & Antiinflammatory Drugs (Pt. II)    --- 29:01


NSAIDs & Antiinflammatory Drugs (Pt. III)    --- 17:00


Endocrines


Anticoagulants/Blood Disorders    --- 38:07


Oral Hypoglycemics/Drugs for Osteoporosis    --- 21:28


Toxic Syndromes


Toxic Syndromes/Antidotes    --- 18:30
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http://hotfile.com/dl/83687332/a84bae9/PHARMACOLOGY.part1.rar.html
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http://hotfile.com/dl/83687346/de8eb3d/PHARMACOLOGY.part2.rar.html
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Notes in Microsoft word format


http://hotfile.com/dl/83602650/debe639/WEBPREP_USMLE_STEP_1_NOTES_in_word_format.rar.html

Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice

Written by experts at the forefront of current research and clinical practice, this volume provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, drug development, and clinical drug trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.
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http://hotfile.com/dl/79508599/7d77742/NPP.chm.html

Handbook of Clinical Drug Data

This classic, authoritative guide to the clinical use of drugs is the superior source of evaluative and comparative information on over 1,200 drugs in common use. Written by 36 top clinicians and edited by three leading drug information specialists, it is the highest quality and most clinically useful drug handbook available. Part 1, Drug Monographs, covers 10 major drug categories, subdivided into therapeutic groups for easy comparison. Unique tables provide data for choosing the optimal drug for specific patients. Part 2, Clinical Drug Data, has everything healthcare professionals need to determine the likelihood of adverse drug reactions and interactions in their patients. Selection of drug therapy for special patient populations is made easy by several comprehensive chapters.


Unique Features

* Comprehensive comparison charts of drugs by class for easy clinical decision making

* Tables that help rapidly identify the cause of adverse drug effects in your patients

* Guides to the optimal choice of drugs in special populations, such as pregnant and breastfeeding women, renal disease, and dialysis

* The only referenced drug handbook--includes over 3,600 literature citations

* Tabbing guide for easy location of drug categories

* Extensive cross-referenced index that includes Canadian and British drug names
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http://hotfile.com/dl/77060750/5ea4caf/Drug_Data.pdf.html

Litt's Drug Eruptions & Reactions Manual, 2010 Edition

In its 16th Edition, this widely acclaimed book has evolved and expanded into the ‘Drug Eruptions and Reactions Manual’ (D.E.R.M.) – an authoritative guide to adverse drug reactions and reaction patterns. With improved adverse-events listing and a new classification system for reaction patterns, Litt’s D.E.R.M. is a valuable resource for anyone dealing with drug prescription. The intuitive look up format and comprehensive coverage make it a helpful diagnostic aid for medical practitioners and an important reference tool for educators, lecturers, pharmacists and students. In retaining its unique focus on drug eruptions, which is much beloved by dermatologists, this edition is also essential for anyone researching, teaching and practicing cutaneous medicine.
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http://uploading.com/files/f529c5f2/DERM.pdf/

The Sanford Guide to Antimicrobial Therapy, 2010

With bioterrorism, avian flu, and drug-resistant infections in the news, doctors need a guide to antimicrobial therapy more than ever.The Sanford Guide to Antimicrobial Therapycontinues to be one of the most frequently used and widely relied upon references in medicine. With ever-increasing challenges posed by new and re-emerging infectious diseases, this concise, well-annotated pocket reference remains a staple in lab coat pockets throughout the world.


New material found in this edition includes updated recommendations for management of community-associated MRSA, treatment options for highly resistant bacteria, and current regimens for antiretroviral therapy. All of the tables have been updated to reflect newly approved drugs, new indications for existing drugs and updated dosage, side effects and pharmacologic data.
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http://hotfile.com/dl/70506067/11f9e93/TSGtAT.pdf.html

A Textbook of Clinical Pharmacology and Therapeutics

If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding.


Fully revised throughout and extensively illustrated, the fifth edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another. The text provides current information on all areas of drug prescribing with updated discussion and guidance on such topics as adverse drug reactions, personalized medicine, gene and cell-based therapy, advances in cancer therapy, and mechanisms of drug action and treatment guidelines in HIV and mycobacterial infections therapy. A new chapter on alternative medicines and nutraceuticals has been introduced and Further Reading lists have been updated to include key medical websites.

All medical students and junior doctors who read this book will learn not only how to use drugs safely and effectively, but, importantly, the rationale behind effective prescribing decisions.
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http://hotfile.com/dl/65680836/d656668/Clinical_Pharmacology.pdf.html

Adverse Drug Interactions: A Handbook for Prescribers - April 2010 Edition

The prescription of two or more drugs for simultaneous use by a patients always raises the possibility that one of those drugs will affect the intensity and duration of effect of the other(s), and can introduce the possibility of serious side effects occurring. This book provides a convenient, user-friendly approach to this problem, providing information on potential adverse affects by drug class. By establishing a system of grading throughout the book and appropriate coding through the use of special icons, the authors highlight immediately to the reader those interactions that are likely to give rise to life-threatening reactions and must therefore be completely avoided in addition to other, less threatening but nonetheless important interactions to be aware of.


Presented in tabular form for ease of reference, the book also provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered and instructions for monitoring patients when adverse effects may occur. All advice is supported by the appropriate evidence, graded according to a university accepted system. Drug naming follows the recommendations of INN. Throughout, interactions with OTC medications, herbal remedies and dietary supplements are also considered.
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http://uploading.com/files/8ea7dd95/Adverse%2BDrug%2BInteractions.pdf/

The Epilepsy Prescriber's Guide to Antiepileptic Drugs - August 2010 Edition

Prescriber's Guide to Antiepileptic Drugs provides a practical and concise reference guide for use by all those clinicians and allied health professionals that treat or care for patients with epilepsy. In full colour throughout, this volume presents the antiepileptic drugs (AEDs) in alphabetical order and for each AED the information is divided into eight coloured sections: general therapeutics, pharmacokinetics, interaction profile, adverse effects, dosing and use, special populations, and suggested reading. This handy pocket guide will be an excellent companion for all clinicians that treat patients with epilepsy.
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http://uploading.com/files/d3afm3ec/Antiepileptic%2BDrugs.pdf/

Pharmacology: PreTest Self-Assessment and Review

Gives medical students 500 questions, answers, and explanations to prepare for the pharmacology section of the USMLE Step 1. The new edition includes many new questions in the two-step clinical format to simulate the USMLE Step 1.


* 500 USMLE-type questions, answers & explanations

* High-yield facts reinforce key concepts

* Targets what you really need to know

* Student-tested and reviewed

PreTest® is the medical student's most dynamic weapon for mastering the USMLE Step 1.

* Designed to simulate the exam

* Reviewed by recent examinees

* Mimics the real exam, question by question

PreTest® is the closest you can get to seeing the test before you take it.

This one-of-a-kind test prep guide helps you:

* Get to know material on course exams and the USMLE Step 1

* Practice with 500 clinically oriented multiple-choice questions

* Review key facts for exam success o Build confidence, skills, and knowledge

There are plenty of answers out there. But only PreTest® delivers USMLE-type questions, in USMLE format.

Open this PreTest® for:

* 500 board-type questions

* High-yield facts for board and course review

* Referenced answers with concise explanations

Great for pharmacology course review and exams, too! This Pharmacology PreTest® asks the right questions so you'll know the right answers. Open it and start learning what's on the test.
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http://hotfile.com/dl/51944883/c8c78a8/Pharmacology_PreTest_Self-Assessment_and_Review.pdf.html

Underground Clinical Vignettes: Pharmacology: Classic Clinical Cases for USMLE Step 1 Review

Blackwell’s Underground Clinical Vignettes: Pharmacology, third edition is your primary source for clinically relevant, case-based material essential for Step 1 review. Each Clinical Vignette presents approximately 100 cases with over 1000 classic buzzwords in Hx, PE, lab, imaging, pathology and treatment.

The revised editions contain:
· High-yield updates to nearly every case
· Links to Basic Science and Clinical Science Color Atlas
· New Cases on commonly tested USMLE topics

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http://hotfile.com/dl/41501546/e639864/UCV_-_PHARMACOLOGY.pdf.html

Handbook of Drugs for Tropical Parasitic Infections

Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical parasitic infections were introduced more than 30 years ago. Most of these drugs are toxic and have complicated dosage regimens, but, because of the low economic incentive, pharmaceutical companies have shown little interest in developing new drugs to control diseases prevalent in developing countries.; However, there has been notable progress in research into parasitic diseases and a number of important drugs have been introduced for some diseases since the 1970s. Moreover, recent data on the pharmacokinetics and field evaluations of these drugs have revealed that their effectiveness can be improved and their safety increased.; This handbook is designed to provide information about the pharmacological properties and therapeutic uses of the major drugs currently employed to combat the human parasitic infections encountered in the tropics. Each of the 38 drugs covered in the book are presented under the following headings: chemical structure, physical properties, pharmacology and mechanism of action, pharmacokinetics, clinical trials, pregnancy and lactation, side effects, contraindications and precautions, dosage, preparations, and references.
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http://www.mediafire.com/?amumojz5jjc

Stockley's Drug Interactions Pocket Companion 2010

Extensively updated to reflect the latest findings and provides busy healthcare professionals with a small and conveniently sized, quick-referenceStockleytext.It draws on the wealth of clinically evaluated, evidence-based information on drug-drug, drug-herb and drug-food interactions that is presented in the full reference work,Stockley's Drug Interactions.

• Follows the familiar format of theStockleyproducts

• Includes nearly 1550 interaction monographs pertaining to specific drugs or drug groups

• Arranged alphabetically for ease of searching

• Contains a comprehensive index

• Easy-to-use severity rating symbols offer guidance to the user on the clinical significance of the interaction

• An essential clinical reference for physicians, pharmacists, nurses and other healthcare professionals.

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http://uploading.com/files/d29c2547/Stockley%27s+drug+Interactions.pdf/

Introduction to Renal Therapeutics

This work gives an introduction to all aspects of drug use in renal failure."Introduction to Renal Therapeutics" is an introduction to all aspects of drug use in renal failure. Covering various diseases affecting the kidneys, each chapter discusses the disease process and treatment. It also addresses the role of the pharmacist in patient care. Case studies and questions and answers are included at the end of each chapter.Written by members of the UK Renal Pharmacy Group, this book will be of particular interest to anyone new to, or planning a career in, renal pharmacy. It will also be of interest to nonspecialists who deal with renal patients and to pharmacy students, and to any healthcare professional with an interest in renal medicine.

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http://uploading.com/files/a82d5fb8/Introduction+to+renal+therapeutics.pdf/

WHO Model Prescribing Information: Drugs Used in Bacterial Infections

Provides model prescribing information for essential drugs used in the treatment of bacterial infections. This new volume includes drugs used for treating respiratory, gastrointestinal, urinary, perioral, dental and cardiovascular infections, as well as septicaemia and infections of the skin, soft tissues, bones and joints, sexually transmitted diseases, and other commonly encountered bacterial infections. It also covers prophylaxis against rheumatic fever, meningitis, and bacterial infection during surgery.

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http://hotfile.com/dl/32057858/2ca49e5/WHO_Model_Prescribing_Information_Drugs_Used_in_Bacterial_Infections.pdf.html